Patterns of atrophy were mostly consistent with the individual clinical presentation, since cases of behavioral and linguistic variants of FTD associated with TARDBP mutations have shown variable combinations of temporal and/or frontal lobe involvement (14, 16, 18, 21), whereas cases of ALS associated with TARDBP mutation reported in literature presented either a normal MRI (15, 17, 32, 33) or mild bilateral temporal atrophy (33). Here, TARDBP is linked to frontotemporal dementia.