In immunocytochemistry, the 2A7 antibody detected a significant 1.4-fold higher aSyn signal intensity in TUBB3 (Tuj1)-positive cells from patients with PD Dupl compared to control neurons (p < 0.01, Figure 5C), close to the theoretical 1.5-fold increase in SNCA gene dosage. Here, SNCA is linked to Parkinson disease.