MTHFR and Scheuermann disease: She was diagnosed with Scheuermann's kyphosis at around 14 years of age, and previous genetic screening for drug metabolism revealed a heterozygous variant of the methylenetetrahydrofolate reductase (MTHFR) gene, NM_005957.5:c.677C>T (NP_005948.3:p.Ala222Val; rs1801133).