TNF and spondylo-ocular syndrome: Similarly, in a study of post-transplant adverse events in pediatric patients (N = 61), Döring et al. (7) report significantly increased levels of IL-6, IL-8, and tumor necrosis factor α (TNF-a) in accompaniment with SOS, and IL-10, sIL2-R, IL-6, and TNF-a with GvHD.