Since all major types of hematopoietic CD45+ cells express the ICAM-1 binding LFA-1 and Mac-1 integrins (46–48), we next tested if the composition of these cells in the E0771 tumor microenvironment (TME) is affected by the absence of E0771-expressed ICAM-1 (Figure 1E). This evidence concerns the gene ITGAL and neoplasm.