Among 227 lactate metabolism-related genes, 37 DEGs in COAD patients of TCGA cohort were identified with FDR< 0.05 and logFC >1, 27 of which were up-regulated (TRMU, TIMM50, POLG2, CHEK2, CFI, CARS2, LDHB, GTPBP3, NDUFAF8, IRAK1, PNPT1, CLPB, CD46, ATAD3A, PDP1, COL4A1, POMK, SLC16A8, HPDL, TWNK, PUS1, KCNN4, MYC, CA5A, HS6ST2, SPP1 and SLC13A3) and 10 were down-regulated (SLC5A12, LDHD, HBB, ACAT1, ACADM, SLC25A42, FLI1, LARGE1, CFH and MPC1). The gene discussed is SPP1; the disease is colon adenocarcinoma.