The role of DNAM-1 in the control of viral infections has been underlined by the absence of control of lymphocytic choriomeningitis virus infection in DNAM-1−/− mice (47), the NK cell recognition of virus-infected cells during early infection (48), and the capacity of DNAM-1+ NK cells to produce high levels of inflammatory cytokines (49). The gene discussed is CD226; the disease is infection.