GW4064 or Obeticholic acid (OCA) as FXR agonists can alleviate the lesion of intestinal mucosa, reduce the permeability of gut parclose, restrict bacterial overgrowth and bacterial translocation in model animals (209–211), suggesting that FXR agonists may have a positive effect on the prevention of liver cancer effect. This evidence concerns the gene NR1H4 and liver cancer.