It demonstrated that cGAS (p < 0.001), IRF3 (p < 0.001), and TBK1 (p = 0.001) had the highest expression levels in Cluster C but were most down-regulated in Cluster A (Supplementary Figure 7A-D), which implied the significance of necroptosis in shaping the tumor immune microenvironment and immune response and further suggested the potential viability of necroptosis in chemotherapy and immunotherapy for LUAD treatment. This evidence concerns the gene IRF3 and neoplasm.