TBK1 and neoplasm: It demonstrated that cGAS (p < 0.001), IRF3 (p < 0.001), and TBK1 (p = 0.001) had the highest expression levels in Cluster C but were most down-regulated in Cluster A (Supplementary Figure 7A-D), which implied the significance of necroptosis in shaping the tumor immune microenvironment and immune response and further suggested the potential viability of necroptosis in chemotherapy and immunotherapy for LUAD treatment.