Another study proved that PD-L1-targeted CAR-T cells exhibited antigen-specific activation, cytokine production, and cytotoxic activity against PD-L1high NSCLC cells and xenograft tumors, and the addition of a subtherapeutic dose of local radiotherapy improved the efficacy of PD-L1-CAR-T cells against PD-L1low NSCLC cells and xenograft tumors (115). This evidence concerns the gene CD274 and non-small cell lung carcinoma.