CD4 and Autoimmunity: In view of the enrichment of transcription factors involved in T-helper cell differentiation pathways in the RNA-seq dataset and implications for IL-6-driven pathogenic Th1 (38), Th17 (39), and Tfh (40) responses in autoimmunity, we focused on CD4+ T cells to better understand the impact of classic IL-6 signaling on T-helper cell subsets in the absence of TCR stimulation.