A research team found that a GM-CSF carrying tumor lysing vaccinia virus JX-594 (pexastimogene devacirepvec, Pexa-Vec) effectively inhibits CRC peritoneal metastasis by selectively infecting and lysing peritoneal tumor cells and activating peritoneal dendritic cells (DCs) and CD8 T cells to restore peritoneal anti-cancer immunity (15). Here, CD8A is linked to neoplasm.