A research team found that a GM-CSF carrying tumor lysing vaccinia virus JX-594 (pexastimogene devacirepvec, Pexa-Vec) effectively inhibits CRC peritoneal metastasis by selectively infecting and lysing peritoneal tumor cells and activating peritoneal dendritic cells (DCs) and CD8 T cells to restore peritoneal anti-cancer immunity (15). This evidence concerns the gene CD8A and colorectal carcinoma.