Previous studies have shown that the Ki-67 score is an important prognostic factor in GBM and a marker of cell proliferation.39–41 Thus, our results demonstrated that PDGFRA gain/amplification causes poor prognoses in patients with IDH wild-type GBM by increasing the proliferative ability of tumors and increasing the rate of incomplete resection of tumors. This evidence concerns the gene PDGFRA and glioblastoma.