The PDGFR signaling pathway activates intracellular signaling pathways, such as the RAS/MAPK and PI3K/AKT pathways, that are involved in cell proliferation, migration, survival, and oncogenesis.5,6 Furthermore, the concept of PDGFRA as a possible drug target for GBM has been gaining attention. The gene discussed is PDGFRA; the disease is glioblastoma.