NTRK1 and glioblastoma: PDGFRA is the second most frequently mutated tyrosine kinase receptor-encoding gene, following EGFR, in glioblastoma (GBM)1,2 and plays an important role in oligodendrocyte differentiation.3 However, amplification of PDGFRA is associated with oligodendroglial morphology and malignancy.4 PDGFRA is a transmembrane receptor comprising 5 immunoglobulin-like extracellular domains and an intracellular tyrosine kinase domain.