MAPT and early-onset autosomal dominant Alzheimer disease: In our study, we found that one of the highly cited articles within Cluster #2, Ossenkoppele et al. (2016) “Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease,” used 18F-AV1451 (a recent PET tracer) to map the pathological distribution of the Tau protein in the brain tissues of Alzheimer’s disease patients.