Similarly, hepcidin, a peptide hormone that seems to modulate the action of ferroportin, has been found to be decreased in AD hippocampi (Raha et al., 2013), while hepcidin’s overexpression in mouse astrocytes protects against β-amyloid-induced neurodegeneration (Zhang et al., 2020). The gene discussed is SLC40A1; the disease is Alzheimer disease.