However, it seems to be secondary—huntingtin (the gene mutated in Huntington’s disease) is involved in iron homeostasis regulation (Hilditch-Maguire et al., 2000), and mutated huntingtin results in increased expression of iron response proteins, inducing iron overload (Chen et al., 2013; Niu et al., 2018). The gene discussed is HTT; the disease is juvenile Huntington disease.