In contrast, while a genetic linkage is not established between genes associated with processing tau and AD (Goedert, 2005), its accumulation in neurofibrillary tangles has a strong correlation with neurodegeneration and memory decline (Duyckaerts et al., 1998; Giannakopoulos et al., 2003; Ingelsson et al., 2004). Here, MAPT is linked to Alzheimer disease.