PITX2 and atrial fibrillation: On multivariate linear regression analyses, PITX2 rs12646447 was independently associated with PV/LA%vol (β = 0.20 [0.05–0.35], p = 0.010, Model 2 in Table 3), but not with the AF recurrence after AFCA (Lon-rank p = 0.368, Figure 2B; HR 0.93 [0.80–1.09], p = 0.371, Table 4).