In model 1, among the variables significantly associated with AF in bivariate analysis, galectin-3 ≥ 9 ng/ml [OR 3.10; 95% CI (1.03–9.254), p = 0.042], NT-pro-BNP ≥ 290 pg/ml [OR 3.950; 95% CI (1.754–8.892, p = 0.001], OPG ≥ 887 pg/ml [OR 2.338; 95% CI (1.015–5.620), p = 0.046] and LAVI ≥ 33.5 ml/m2 [OR 2.982; 95% CI (1.342–6.625), p = 0.007] were independently associated with AFDAS. This evidence concerns the gene NPPB and atrial fibrillation.