In model 2, including HRV variables, galectin-3 ≥ 9 ng/ml [OR 6.587; 95% CI (1.529–28.376) p = 0.011], NT-Pro-BNP ≥ 290 pg/ml [OR 4.676; 95% CI (1.655–13.210), p = 0.004], OPG ≥ 887 pg/ml [OR 3.350; 95% CI (1.060–10.590) p = 0.040] and pNN50 ≥ 11 [OR 8.260; 95% CI (2.795–24.406), p < 0.001] were independently associated with AFDAS after discharge from the stroke unit. Here, NPPB is linked to stroke disorder.