Although P-selectin, thromboglobulin, and MTHFR, a key modulator of purine and thymidylate biosynthesis, play a critical role in thrombosis (80, 81), and their alterations have been observed in subjects with depression (82, 83), definitive potential relationship with BDNF is actually missing. The gene discussed is MTHFR; the disease is major depressive disorder.