Promising for the prevention and treatment of diabetic cardiomyopathy; improve the NO-sGC-cGMP-cascade thus attenuating myocardial oxidative stress and cardiac inflammation; reduce cardiovascular mortality in HFrEF and HFpEF; exhibit cardiovascular benefits by increasing the circulating and tissue levels of β-hydroxybutyrate; improve hemodynamics in HF. This evidence concerns the gene SGCB and hydrops fetalis.