GABRG2 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Based on our studies on other epilepsy mouse models Gabrg2+/- and Gabrg2+/Q390X, a small increase of γ2 subunit reduces seizure severity from Dravet syndrome to infrequent absence or seizure free.34,35 This is likely true for the PBA-treated mice.