RS1 and X-linked retinoschisis: Intravitreal injection of an AAV8 vector carrying the Retinoschisis 1 gene (RS1) in a mouse model with X-linked retinoschisis, caused by a mutation in the RS1 gene, exhibited significant improvement in retinal structure and function post-treatment and has moved to a phase 1/2 clinical trial (NCT02317887) (91).