Under this premise, we found there were statistical differences in the age of onset, the course of the disease, the proportion of EGPA, BVAS, WBC, HB, N, ESR, CRP, ALT, ALB, BUN, and 1-year mortality ratio between male and female patients with AAV. This evidence concerns the gene ESR1 and anti-neutrophil cytoplasmic antibody-associated vasculitis.