TFAP2A and Nasolacrimal duct obstruction: Tekin et al. identified a heterozygous deletion/insertion mutation in the TFAP2A gene in a 4-year-old Turkish girl with Branchiooculofacial syndrome which is characterized by branchial cleft sinus defects, ocular anomalies such as microphthalmia and lacrimal duct obstruction, and a dysmorphic facial appearance (including cleft or pseudocleft lip/palate).