We assessed differences in immune cells in the tumor microenvironment between high-risk and non-high-risk groups and found a higher proportion of Plasma cells, memory B cells, activated memory CD4 T cells, Neutrophils and a lower proportion of resting memory CD4 T cells, M2 macrophages, activated mast cells were generally contained in high-risk category primary neuroblastomas tissues, suggesting that this is an immune apathetic tumor (38). This evidence concerns the gene CD4 and neuroblastoma.