RRM2 and cancer: As shown in Figure 1A, we found that there was no significant change in RRM2 expression in KICH compared with normal tissues, but RRM2 expression was significantly increased in the remaining 17 cancer types, including BLCA, BRCA, CHOL, COAD, ESCA, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, STAD, THCA, and UCEC.