As presented in Table 2, RRM2 was significantly positively related to dendritic cell’s biomarkers (HLA-DPB1, HLA-DPA1, HLA-DRA, ITGAX, and NRP1), B cell’s biomarkers (CD79A and CD19), M2 macrophage’s biomarkers (MS4A4A and VSIG4), CD4 + T cell’s biomarker (CD4), CD8 + T cell’s biomarkers (CD8A and CD8B), neutrophil’s biomarkers (ITGAM) and M1 macrophage’s biomarkers (IRF5) in HCC. The gene discussed is HLA-DPA1; the disease is hepatocellular carcinoma.