ACE and pericarditis: To date, there are no randomized clinical trials or observational studies that compare withholding medication vs trial of steroids for treatment of 5-ASA-induced pericarditis [66]. Other medical therapies include cardioprotective agents (beta-blockers, ACE-inhibitors), anti-inflammatories (aspirin, metamizole), and MTX (note: it is unclear if this patient was given MTX as a new maintenance medication for IBD or for treatment of the pericarditis). Four patients with pericarditis required drainage either via a subxiphoid pericardial window or pericardiocentesis.