TLR4 and chronic obstructive pulmonary disease: However, the expressions of MYD88, p–NF–κBp65/NF-κBp65, TLR4, and TLR2 in the lung tissues of the COPD + MB group and COPD + HB group were lower than those of the COPD group (P < 0.05 or P < 0.01), but the expression of p-IκBa/IκBa was remarkably higher than that of the COPD group (P < 0.05 or P < 0.01).