In our study, when giving BA treatment, it could reduce the levels of TLR2, MYD88, TNF-α, and IL-1β mRNA, thereby reduce the expressions of MYD88, p–NF–κBp65/NF-κBp65, TLR4, and TLR2, indicating that BA could downregulate the TLR2/MYD88/NF-κBp65 signaling pathway, which is similar to the BA inhibiting TLR2/MYD88/NF-κB signaling pathway to reduce inflammation in fever rats [15, 35]. The gene discussed is NFKB1; the disease is Fever.