With an increase in the dosage of the traditional Chinese medicine compound JPXZF, the relative mRNA and protein expression levels of GRP78 and ATF6 in the liver of the rats in each intervention group were decreased in a dosage-dependent manner, which indicated that JPXZF attenuated or prevented ERS in rats. The gene discussed is HSPA5; the disease is amelogenesis imperfecta type 1G.