Xie et al. [48] found that the overexpression of FAM134B reduced ERS, reporting that the expression of C/-EBP homologous protein (CHOP) and GRP78 was decreased and that neuronal apoptosis was induced by epileptic seizures, but the downregulation of FAM134B expression led to the opposite effects. The gene discussed is HSPA5; the disease is Seizure.