Subsequently, the abovementioned significant parameters were included in the multivariate regression analysis (Tables 3 and 4), and the result showed that the number of tumor nodules, tumor diameter, AFP, AFP-L3, and the presence of liver cirrhosis were all independent risk factors for liver cancer recurrence within one year (P < 0.05) except for age (P > 0.05). Here, AFP is linked to cirrhosis of liver.