In the study of Cho et al. [29] on prostate cancer, it was found that that epidermal growth factor promotes prostate cancer cell invasion and metastasis by promoting reactive oxygen species production, which in turn drives STAT3 phosphorylation and regulates the HIF-1α/TWIST1/N-cadherin (N-cadherin) signaling pathway. The gene discussed is CDH2; the disease is Familial prostate cancer.