CHAF1A expression was also found to be strongly associated with family history of GC (χ2 = 7.826, p=0.005), smoking history (χ2 = 5.826, p=0.016), T stage (χ2 = 10.989, p=0.001), tumor marker CEA (χ2 = 4.870, p=0.027), tumor marker AFP (χ2 = 5.672, p=0.017), and PD-L1 expression (χ2 = 4.776, p=0.029) (Table 3). Here, CD274 is linked to gastric cancer.