MAPK8 and attention deficit-hyperactivity disorder: In this study, our purpose was to explore whether ASDZL affects the function of the SNARE complex by regulating the BDNF/TrkB signaling pathway or downregulating the expression levels of the main factors (P75, JNK1, and NF-κB) that inhibit the activation of related pathways and play a regulatory role in the initial process of vesicle circulation in the prefrontal cortex (PFC), corpus striatum, and hippocampus of ADHD model SHRs.