Interestingly, the few low molecular weight proteins that seemed to remain unaffected through in vitro digestion presented similar molecular weight to the bioactive protein reported previously for chickpea and lupin, which contains high inhibitory bioactivities toward the gelatinases MMP-9 and MMP-2 (23, 24), particularly in lupin, where a low molecular weight oligomer with strong MMP-9 inhibitory activity was found to survive proteolysis during digestion and is effective in reducing colitis in vivo (24). The gene discussed is MMP2; the disease is colitis.