Noticing the function of PGC-1α in the thermogenic brown adipose tissue (BAT) program, the regulation of Glut-4 and mitochondrial oxidation in muscle, and the dominant role of PGC-1α in hepatic gluconeogenesis along with the promotion of muscle tissue remodeling activity, all of which suggest that this co-activator can be a target for anti-obesity, antidiabetic, and anti-aging supplements (chronic diseases and aging) (11–13). Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.