In APOE4-negative subjects with baseline MMSE score of ≥14:Increased: Mini-Mental State Examination scores No change: Alzheimer's Disease Assessment Scale (ADAS) scores In APOE4-negative subjects with baseline MMSE score of <14 and APOE4-positive subjects:No change: Mini-Mental State Examination scores Alzheimer's Disease Assessment Scale (ADAS) scores. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.