Improved: Performance on the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog); ApoE4(-) subjects (Days 45 and 90).  No change: Performance on the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog); ApoE4(+) subjects. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.