MUS81 silencing gene made mice susceptible to spontaneous tumors [12], and the expression of MUS81 decreased in liver cancer [13], colorectal cancer [15], and gastric cancer [14] as well as high malignant astrocytoma [29], which linked to tumor stage, grade, metastasis, and prognosis. Here, MUS81 is linked to astrocytoma (excluding glioblastoma).