In addition to the above three common regulators, other regulators can be used to treat or relieve the symptoms of neurological disorders, such as PINK1, Ca2+, Sigma-1 receptor (sig-1R), peroxidase (prx), toll-like receptors (TLRs), and alarmins/c-jun N-terminal kinase (JNK) [151]. This evidence concerns the gene MAPK8 and nervous system disorder.