As a free radical scavenger [100], Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one, EDA) can improve depression and anxiety-like behavior, as well as inhibit oxidative stress and neuroinflammation in a mouse model of depression, and knocking down of GPX4 expression in CSDs mouse model can inhibit the therapeutic effect of EDA on depression and anxiety [101]. This evidence concerns the gene GPX4 and major depressive disorder.