In this study, hierarchical clustering analysis identified a set of ISGs (e.g., IFITM1/2/3, BST2, and SLC16A1) that were highly induced in the early stages of WSN infection (1 dpi), while the levels of interferons IFNB1, IFNL1 and IFNL2 are upregulated only in late stages of infection (4 dpi) (Figure 3F), indicating intracellular response to virus infection at different stage. The gene discussed is IFNL1; the disease is infection.