TNF and neoplasm: Moreover, Ou et al. reported a PLGA NP modified by GITR antibody that was a kind of tumor necrosis factor (TNF) receptor family-related proteins, which simultaneously encapsulated imatinib (IMT) into the core of the nanocarrier via hydrophobic forces and absorbed the positively charged PS IR-780 on the polymeric shell by electrostatic interaction, thus quickly damaging tumor cell membrane during PDIT 48.