PDCD1 and breast carcinoma: During this combination strategy, phthalocyanine dye-labeled probe could evoke powerful antitumor efficacy of PDT by generating sufficient ROS under 690 nm laser, and anti-PD-1 antibody could achieve the specific blockade of checkpoint PD-1 for impeding immune escape of tumors, ultimately effectively suppressing breast cancer growth and lung metastasis 141.