Additionally, Chen et al. constructed a pH-responsive dextran NP co-loaded with the PS zinc phthalocyanine and anti-CTLA4 antibody to apply in 4T1 tumor-bearing mouse models, which could induce an abundant activation of T cells through blocking CTLA4, effectively eliminating breast tumor cells during PDIT (Figure 8E)143. The gene discussed is CTLA4; the disease is breast neoplasm.