PTGS2 and colorectal carcinoma: Indeed, validation with CRC cells confirmed that both the protein and mRNA levels of COX2 were increased by DCLK1-B OE and decreased by DCLK1-B KO, DCLK1-A KD, or DCLK1 kinase inhibition (Figure 3D and Figure S4B-E), suggesting a strong relationship between DCLK1 and COX2.