DCLK1 and colorectal carcinoma: Moreover, the phosphorylation status of XRCC5 was altered by modulating DCLK1 expression in multiple CRC cells, as indicated by the increase observed upon DCLK1-B OE and decrease detected upon DCLK1-B KO, DCLK1-B KD, or DCLK1-A KD (Figure 3F and Figure S5B).