Consistent with these results, it was shown that UroA treatment of PDAC cells blocked the phosphorylation of AKT and p70S6K in vitro, successfully inhibiting the growth of tumor xenografts, and increased overall survival of Ptf1aCre/+;LSL-KrasG12D/+;Tgfbr2flox/flox (PKT) mice compared with vehicle or gemcitabine therapy 79. Here, AKT1 is linked to neoplasm.