DLBCL: Diffuse large B-cell lymphoma; R-CHOP: Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone; NHL: Non-hodgins lymphoma; BCL-2: B-cell leukemia/lymphoma-2; CLL: Chronic lymphocytic leukemia; SLL: Small lymphocytic lymphoma; AML: Acute myeloid leukemia; ORR: Overall response rate; AGK: Acylglycerol kinase; CCK-8: Cell Counting Kit-8; CHIP: Chromatin immunoprecipitation. The gene discussed is STUB1; the disease is B-cell chronic lymphocytic leukemia.