Furthermore, CDG stimulated the production of IFNs via the STING pathway, which synergistically re-educates TAMs to a pro-inflammatory phenotype, as well as synergizes M1 microglia and macrophages to phagocytosis of tumor cells in the orthotopic GBM models to substantially improve anti-CD47 blockade efficacy. The gene discussed is CD47; the disease is neoplasm.