Interestingly, our study confirmed that EGR1 expression is an early response by which the kidney alleviates injury and promotes regeneration after AKI, and EGR1 was also reported up-regulated in patients with CKD 21, while EGR1 deficiency attenuated the normal responses of tubular cells to inflammatory factors and alleviated renal fibrosis in tubule interstitial nephritis. The gene discussed is EGR1; the disease is chronic kidney disease.