EGR1 and renal fibrosis: Interestingly, our study confirmed that EGR1 expression is an early response by which the kidney alleviates injury and promotes regeneration after AKI, and EGR1 was also reported up-regulated in patients with CKD 21, while EGR1 deficiency attenuated the normal responses of tubular cells to inflammatory factors and alleviated renal fibrosis in tubule interstitial nephritis.