The chemokine CXCL1 (Keratinocyte derived chemokine-KC) is upregulated in acne, acting as neutrophil chemoattractant, and CXCL2 (SDF-1)—produced by macrophages—is also upregulated and operates to attract polymorphonuclear leukocytes (Li et al., 2019). The gene discussed is CXCL2; the disease is acne.