Successful phages to treat acne might be related to the regulation in the expression of receptors such as TLR-2, TLR-4, and CD36; reduction of the activity of inflammasomes (specially NLRP3) and NF-κB; and modulation of lymphocyte and other immune cells chemoattraction by reducing KC, CXCL2, and IL-8 chemokines. The gene discussed is CXCL2; the disease is acne.