PTEN and PTEN hamartoma tumor syndrome: The alterations and decreased biodiversity were similar to microbiota studies of IBD (Xu et al., 2018), CRA (Feng et al., 2015), CRC, colitis-associated cancer (CAC), sporadic cancer (SC) (Mima et al., 2016; Richard et al., 2018; Wang et al., 2020), PTEN hamartoma tumor syndrome (PHTS) (Jia et al., 2021), and familial adenomatous polyposis (Dejea et al., 2018).