STK11 and Peutz-Jeghers syndrome: LKB1 regulates inflammation and particular inflammatory cytokines, including cyclooxygenase (COX)-2, interleukin (IL)-6, and IL-11, and stimulates intestinal polyposis and gastrointestinal tumorigenesis in patients with PJS and animal models (De Leng et al., 2003; Udd et al., 2004; Ollila et al., 2018; Poffenberger et al., 2018).