IL4 and neoplasm: The secreted IL-33 recruited and activated Th2 and innate lymphoid cells 2 (ILC2) in the tumor microenvironment (TME), which stimulated tumor growth by secreting pro-tumor cytokines, such as IL-4, IL-5, and IL-13 (Chevalier et al., 2017; Alam et al., 2022).