These cell wall components are believed to be recognized by different CLRs, including Dectin-1 (CLEC7A, CLECSF12), Dectin-2 (CLEC6A, CLEC4N, and CLECSF10), Dectin-3 (CLEC6, CLEC4D, CLECSF8, and MCL), Mincle (CLEC4E, CLECSF9), DC-SIGN (CLEC4L), DCIR (CLEC4A, CLECSF6), etc. Over the past 20 years, CLRs have been shown to play a key role in initiating the host immune response against fungal infection (Brown, 2011; Wüthrich et al., 2012; Wevers et al., 2013; Dambuza and Brown, 2015; Underhill and Pearlman, 2015). Here, CLEC4E is linked to fungal infectious disease.