Whereas Dectin-1 activation inhibited Toll-like receptor 4 (TLR4) signaling in hepatic inflammatory and stellate cells by attenuating the TLR4 and its co-receptor CD14 expression, thereby suppressing liver fibrosis and hepatocarcinogenesis (Figure 3A; Seifert et al., 2015). The gene discussed is TLR4; the disease is Hepatic fibrosis.