Recently, Aykut et al. (2019) pioneered the discovery that fungi can migrate from the intestinal lumen to the pancreas and those pathogenic fungi can promote pancreatic ductal adenocarcinoma (PDA) by activating the mannose-binding lectin (MBL)-complement-3 (C3) pathway. This evidence concerns the gene MBL2 and pancreatic ductal adenocarcinoma.