Through Elisa verification of a large number of clinical specimens and western-blot verification of aortic tissue specimens, we concluded that: Lumican, PI16, MMP9, and FGL1 protein may be a potential biomarker in patients with aortic dissection, and the pathogenesis of aortic dissection may be related to lumican mediated TGF-β1 pathway. Here, TGFB1 is linked to Aortic dissection.