INS and metabolic disease: Therefore, this review proposes that MHO is in the state of “micro metabolic disorder.” Although this series of micro metabolic disorders did not cause the indexes of blood lipid and insulin resistance to exceed the standard range, when the body is stimulated by the same internal and external environment, compared with the healthy control, due to the abnormal micro metabolism of MHO, the body’s ability to regulate balance or compensate metabolism becomes smaller, which is more likely to destroy the metabolic homeostasis, which can lead to disease in the long run.