The top 20 terms of KEGG pathway were listed as metabolic pathways, alcoholism, systemic lupus erythematosus, cell cycle, viral carcinogenesis, pathways in cancer, PI3K-Akt signaling pathway, necroptosis, human T cell leukemia virus infection, calcium signaling pathway, MAPK signaling pathway, cellular senescence, DNA replication, oocyte meiosis, progesterone-mediated oocyte maturation, Fanconi anemia pathway, homologous recombination, p53 signaling pathway, arrhythmogenic right ventricular cardiomyopathy, and base excision repair (Figure 3(f)). This evidence concerns the gene AKT1 and alcohol dependence.